A substance or activity that enhances or increases the potency or effectiveness of another substance. In the context of the cytochrome P450 system, potentiators can increase the metabolic breakdown of certain substances, leading to increased elimination from the body and reduced potency. Examples of potentiators include certain foods, supplements, and medications that affect the activity of cytochrome P450 enzymes, which play a role in the metabolic elimination of drugs and other substances from the body. Common potentiators include:

Alcohol – A colorless, volatile liquid that is produced by the natural fermentation of sugars. Alcohol is commonly used as a solvent, but can also enhance the effects of certain substances.

Methyl Alcohol: Also known as methanol and ‘rubbing alcohol’, is a toxic alcohol used as a solvent, fuel, and antifreeze in industry. It is not meant for consumption as it is highly toxic even in small amounts.

Ethyl Alcohol: Also known as ethanol, is the type of alcohol found in alcoholic beverages and is used for recreational and medicinal purposes. Ethanol is significantly less toxic than methanol and is considered safe for consumption in moderate amounts. It is not recommended to mix ethyl alcohol with kratom or kava.

Apple Cider Vinegar – A type of vinegar made from fermented apples that is commonly used in cooking, as a natural cleaning agent, and for its potential health benefits, including weight management and blood sugar control.

Ashwagandha – An herb commonly used in Ayurvedic medicine, traditionally believed to help with stress, anxiety, and other health issues.

Blue Lotus – A water lily plant native to Egypt, commonly used for its calming and relaxing effects and anecdotally for medicinal purposes.

Black Pepper – A common spice made from dried and ground peppercorns that has been shown to enhance the effects of certain substances, particularly compounds that are metabolized through the cytochrome P450 system.

Cayenne – A type of chili pepper that is commonly used in cooking, but also has potential health benefits, including pain relief and reducing inflammation.

Cinnamon – A spice commonly used in cooking and baking, but also used for its potential health benefits, including improving blood sugar control and reducing inflammation.

Citrus Bioflavonoids – A class of compounds found in citrus fruits that have been shown to enhance the effects of certain substances, particularly compounds that are metabolized through the cytochrome P450 system. Commonly used as Citric Acid.

Damiana – An herb native to Mexico and Central and South America, commonly used for its relaxing and aphrodisiac effects, as well as for medicinal purposes.

Devil’s Claw – A plant native to Southern Africa, the root of which is commonly used for pain relief, especially in cases of osteoarthritis and low back pain.

Echinacea – A type of flowering plant native to North America, commonly used as an herbal supplement to help boost the immune system and prevent colds and other infections.

Ginger – A root commonly used in cooking and for its potential health benefits, including reducing nausea and vomiting, reducing inflammation, and relieving pain.

Grapefruit Juice – A type of fruit juice made from freshly squeezed grapefruit that has been shown to enhance the effects of certain substances, particularly compounds that are metabolized through the cytochrome P450 system.

Magnesium Citrate – A form of magnesium, a mineral, commonly used as a dietary supplement for its potential health benefits, including reducing anxiety and improving sleep quality.

Milk Thistle – An herbal supplement made from the seeds of the milk thistle plant that has been shown to enhance the effects of certain substances, particularly compounds that are metabolized through the cytochrome P450 system.

Orange Peel – The outer layer of an orange, commonly used as a natural cleaning agent, as well as for its potential health benefits, including reducing inflammation and improving gut health.

Peppermint – A type of mint plant that is commonly used for its cooling and refreshing flavor and for its potential health benefits, including reducing nausea and improving digestion.

Shatavari – An herb native to India, commonly used in Ayurvedic medicine for its potential health benefits, including improving hormonal balance, supporting reproductive health, and reducing stress and anxiety.

Skullcap – A type of flowering plant native to North America, commonly used as an herbal supplement to help reduce anxiety, insomnia, and other nervous conditions.

Slippery Elm Bark – A type of tree native to North America, the bark of which is commonly used as an herbal supplement to help reduce inflammation and improve digestive health.

Tongkat Ali – An herb native to Southeast Asia, commonly used as a natural remedy for boosting energy levels, improving athletic performance, and increasing libido.

Tribulus – A type of plant native to warm climates, commonly used as an herbal supplement to help improve athletic performance, increase energy levels, and boost libido.

Turmeric – A common spice made from the root of the turmeric plant, a type of plant native to South Asia, that has been shown to enhance the effects of certain substances, particularly compounds that are metabolized through the cytochrome P450 system. Turmeric root is commonly used as a spice and for its potential health benefits, including reducing inflammation and improving brain function.

Valerian Root – An herb native to Europe and Asia, commonly used as a natural remedy for reducing anxiety, improving sleep quality, and reducing pain.

Watercress – A type of leafy green vegetable native to Europe and Asia, commonly used for its potential health benefits, including improving gut health, reducing inflammation, and boosting the immune system.

Wild Lettuce – A type of plant native to Europe, commonly used for its potential health benefits, including reducing pain, improving sleep quality, and reducing anxiety.

White Willow Bark – A type of tree native to Europe and Asia, the bark of which is commonly used